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The glucose intolerance and impaired glucose lowering effect of insulin in Insr P1195L/ +/HFD mice resemble those in LIRKO mice 3,7

This suggests that the antioxidant response provided by NRF2 is not required for liver survival in the absence of GSH

Good electron flow = healthy, energetic, long life Poor electron flow = low energy shorter lifespan/healthspan No electron flow = death Anything that impedes the flow of electrons in the body or robs them from the cells and tissues has negative health consequences

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Sources include amalgam dental fillings containing mercury, contaminated seafood, lead in older plumbing systems and paint, cadmium from cigarette smoke and contaminated foods, and arsenic in some water supplies and agricultural products